Time Lines of Infection and Disease in Human Influenza: A Review of Volunteer Challenge Studies
Identifieur interne : 000231 ( France/Analysis ); précédent : 000230; suivant : 000232Time Lines of Infection and Disease in Human Influenza: A Review of Volunteer Challenge Studies
Auteurs : Fabrice Carrat [France] ; Elisabeta Vergu [France] ; Neil M. Ferguson [Royaume-Uni] ; Magali Lemaitre [France] ; Simon Cauchemez [Royaume-Uni] ; Steve Leach [Royaume-Uni] ; Alain-Jacques Valleron [France]Source :
- American Journal of Epidemiology [ 0002-9262 ] ; 2008.
Abstract
The dynamics of viral shedding and symptoms following influenza virus infection are key factors when considering epidemic control measures. The authors reviewed published studies describing the course of influenza virus infection in placebo-treated and untreated volunteers challenged with wild-type influenza virus. A total of 56 different studies with 1,280 healthy participants were considered. Viral shedding increased sharply between 0.5 and 1 day after challenge and consistently peaked on day 2. The duration of viral shedding averaged over 375 participants was 4.80 days (95% confidence interval: 4.31, 5.29). The frequency of symptomatic infection was 66.9% (95% confidence interval: 58.3, 74.5). Fever was observed in 37.0% of A/H1N1, 40.6% of A/H3N2 (p = 0.86), and 7.5% of B infections (p = 0.001). The total symptoms scores increased on day 1 and peaked on day 3. Systemic symptoms peaked on day 2. No such data exist for children or elderly subjects, but epidemiologic studies suggest that the natural history might differ. The present analysis confirms prior expert opinion on the duration of viral shedding or the frequency of asymptomatic influenza infection, extends prior knowledge on the dynamics of viral shedding and symptoms, and provides original results on the frequency of respiratory symptoms or fever.
Url:
DOI: 10.1093/aje/kwm375
Affiliations:
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Ferguson</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Lemaitre, Magali" sort="Lemaitre, Magali" uniqKey="Lemaitre M" first="Magali" last="Lemaitre">Magali Lemaitre</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Université Pierre et Marie Curie-Paris6, UMR-S 707, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>INSERM, UMR-S 707, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Cauchemez, Simon" sort="Cauchemez, Simon" uniqKey="Cauchemez S" first="Simon" last="Cauchemez">Simon Cauchemez</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Leach, Steve" sort="Leach, Steve" uniqKey="Leach S" first="Steve" last="Leach">Steve Leach</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Health Protection Agency, Centre for Emergency Preparedness and Response, Porton Down, Salisbury, Wiltshire</wicri:regionArea><wicri:noRegion>Wiltshire</wicri:noRegion></affiliation></author><author><name sortKey="Valleron, Alain Jacques" sort="Valleron, Alain Jacques" uniqKey="Valleron A" first="Alain-Jacques" last="Valleron">Alain-Jacques Valleron</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Université Pierre et Marie Curie-Paris6, UMR-S 707, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>INSERM, UMR-S 707, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Assistance Publique Hôpitaux de Paris, Hôpital Saint-Antoine, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">American Journal of Epidemiology</title><idno type="eISSN">1476-6256</idno><idno type="ISSN">0002-9262</idno><imprint><publisher>Oxford University Press</publisher><date when="2008-04-01">2008</date><date type="e-published" when="2008-01-29">2008</date><biblScope unit="vol">167</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="775">775</biblScope><biblScope unit="page" to="785">785</biblScope></imprint><idno type="ISSN">0002-9262</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0002-9262</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">The dynamics of viral shedding and symptoms following influenza virus infection are key factors when considering epidemic control measures. The authors reviewed published studies describing the course of influenza virus infection in placebo-treated and untreated volunteers challenged with wild-type influenza virus. A total of 56 different studies with 1,280 healthy participants were considered. Viral shedding increased sharply between 0.5 and 1 day after challenge and consistently peaked on day 2. The duration of viral shedding averaged over 375 participants was 4.80 days (95% confidence interval: 4.31, 5.29). The frequency of symptomatic infection was 66.9% (95% confidence interval: 58.3, 74.5). Fever was observed in 37.0% of A/H1N1, 40.6% of A/H3N2 (p = 0.86), and 7.5% of B infections (p = 0.001). The total symptoms scores increased on day 1 and peaked on day 3. Systemic symptoms peaked on day 2. No such data exist for children or elderly subjects, but epidemiologic studies suggest that the natural history might differ. The present analysis confirms prior expert opinion on the duration of viral shedding or the frequency of asymptomatic influenza infection, extends prior knowledge on the dynamics of viral shedding and symptoms, and provides original results on the frequency of respiratory symptoms or fever.</div></front></TEI><affiliations><list><country><li>France</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Île-de-France</li></region><settlement><li>Londres</li><li>Paris</li></settlement></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Carrat, Fabrice" sort="Carrat, Fabrice" uniqKey="Carrat F" first="Fabrice" last="Carrat">Fabrice Carrat</name></region><name sortKey="Carrat, Fabrice" sort="Carrat, Fabrice" uniqKey="Carrat F" first="Fabrice" last="Carrat">Fabrice Carrat</name><name sortKey="Carrat, Fabrice" sort="Carrat, Fabrice" uniqKey="Carrat F" first="Fabrice" last="Carrat">Fabrice Carrat</name><name sortKey="Carrat, Fabrice" sort="Carrat, Fabrice" uniqKey="Carrat F" first="Fabrice" last="Carrat">Fabrice Carrat</name><name sortKey="Lemaitre, Magali" sort="Lemaitre, Magali" uniqKey="Lemaitre M" first="Magali" last="Lemaitre">Magali Lemaitre</name><name sortKey="Lemaitre, Magali" sort="Lemaitre, Magali" uniqKey="Lemaitre M" first="Magali" last="Lemaitre">Magali Lemaitre</name><name sortKey="Valleron, Alain Jacques" sort="Valleron, Alain Jacques" uniqKey="Valleron A" first="Alain-Jacques" last="Valleron">Alain-Jacques Valleron</name><name sortKey="Valleron, Alain Jacques" sort="Valleron, Alain Jacques" uniqKey="Valleron A" first="Alain-Jacques" last="Valleron">Alain-Jacques Valleron</name><name sortKey="Valleron, Alain Jacques" sort="Valleron, Alain Jacques" uniqKey="Valleron A" first="Alain-Jacques" last="Valleron">Alain-Jacques Valleron</name><name sortKey="Vergu, Elisabeta" sort="Vergu, Elisabeta" uniqKey="Vergu E" first="Elisabeta" last="Vergu">Elisabeta Vergu</name><name sortKey="Vergu, Elisabeta" sort="Vergu, Elisabeta" uniqKey="Vergu E" first="Elisabeta" last="Vergu">Elisabeta Vergu</name><name sortKey="Vergu, Elisabeta" sort="Vergu, Elisabeta" uniqKey="Vergu E" first="Elisabeta" last="Vergu">Elisabeta Vergu</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Ferguson, Neil M" sort="Ferguson, Neil M" uniqKey="Ferguson N" first="Neil M." last="Ferguson">Neil M. Ferguson</name></region><name sortKey="Cauchemez, Simon" sort="Cauchemez, Simon" uniqKey="Cauchemez S" first="Simon" last="Cauchemez">Simon Cauchemez</name><name sortKey="Leach, Steve" sort="Leach, Steve" uniqKey="Leach S" first="Steve" last="Leach">Steve Leach</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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